Excel find highest value in range
don't turn off the lights
2011.12.16 20:49 NewThowAway191 don't turn off the lights
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2018.08.16 03:57 verbalstuntman Market 76: A Fallout 76 Market
Welcome to Market 76, a place to buy and sell items with caps, or to trade with fellow Fallout 76 players. Happy Trading!
2016.01.18 05:28 The working class hero
A spectre is haunting The United States of America.
2023.05.29 17:50 TimoCor Rearranging cells from a list to a specific shape in order to form a map overlay.
For a project in uni, I collected data from a model that I put in a column. An example of such a column is shown below, where baseline means one run of results. As you can see each grid has an attached coordinate. To present my results I am trying to overlay these results over a map, to visualise it better. To this end what I am trying to do is shown in the table 'coordinate map'. Each coordinate would take a spot in that table, I could get an outline of the map over that table and that would create my desired result. Suggestions of other methods of getting such a result are also welcome but for now I am trying this.
Additional info:
As there are only 96 total grids with data, I could put those in manually for one run, but I have to repeat it for 13 runs and that is just a bit too much work where mistakes may creep in. I had a few ideas with no success so far 1) I try and use a SUMIF or IF function to somehow only add the values to the 'coordinate map' cell of 58,7 if the cell grid coordinate has value 58,7. I don't see how to this though as the list is one column and the map is a table. 2) find a way to fill colour cells according to a scale as in conditional formatting, but again, the condition would be based out of the list and in a different format.
I feel like there would be a way to attribute the value of the list to the coordinate map table automatically if the coordinate of the tablecell equals that of the coordinate in the list, but I can't seem to find it. I would be very grateful for any suggestions to do this or another method that I can use to visualise this result.
Kind regards,
Timo
The data I obtained from my model, there are 96 grids with values from 0-4. The coordinate table I am trying to use as a means to show the results from the list in a more visual way. submitted by
TimoCor to
excel [link] [comments]
2023.05.29 17:50 coolbrze77 Fear, Anxiety, Hate & the current conservative world
| I myself was a registered Republican for 30+ years. After moving to and living in the great state of Massachusetts I personally saw the benefit of moving away from the conservative fear based mindset. After 9/11 many people, out of a real fear moved towards the right. I was in MA then. As time passed it became more clear to me that the liberally implemented policies were in fact in the interest of the people. I had the best health care in my life in MA. I’ve lived in NY, MA, FL & IL. MassHealth is what the National Healthcare system was based on. Ironically in liberal MA it works way better than nationally for overtly obvious reasons. $5 script co pays, $0 office visits. They have it down. It was also the least stressful time for me so my conservative values weren’t being gaslit or triggered which provided me clarity. Now unenrolled I see all the fear and anxiety coupled with ignorance fed to the right by disinformation, misinfo and outright lies. That said I am not saying it doesn’t exist on the left side. However on the right they are much more absolutely susceptible and negatively affected by it. Below is an article from Psychology Today. It attempts to break down the ‘why’ conservatives are drawn to fear like a ‘moth to a flame’. Peer-reviewed research shows that conservatives are generally more sensitive to threat. While this threat-bias can distort reality, fuel irrational fears, and make one more vulnerable to fear-mongering politicians, it could also promote hypervigilance, perhaps making one better prepared to handle an immediate threat. (All numbered topics below are expanded upon in the source article) - Conservatives tend to focus on the negative.
- Conservatives have a stronger physiological response to threats.
- Conservatives fear new experiences.
- Conservatives’ brains are more reactive to fear.
Empirical evidence suggests that conservatives and liberals don’t just have different outlooks and opinions—they also have different brains. This means that our choice of political affiliation and overall worldview may not really be all that much of a choice. Still, we must work to understand these psychological and biological distinctions so that we can ultimately use this knowledge to work together and find middle ground. Such information may also make us less vulnerable to those who want to exploit these dispositions for their own selfish agendas by using tactics like fear-mongering. You can change. I’m living proof. Source material: https://www.psychologytoday.com/us/blog/mind-in-the-machine/201612/fear-and-anxiety-drive-conservatives-political-attitudes submitted by coolbrze77 to conservativeterrorism [link] [comments] |
2023.05.29 17:50 Trans_Landscaping Landscaping Puyallup, Washington
| "Beautiful Landscaping in Puyallup, WA: Trans Landscaping Provides Customized Solutions" If you're looking for beautiful and functional landscaping in Puyallup, WA, look no further than Trans Landscaping. Our team of experts has years of experience in designing and installing custom landscapes that fit your needs and budget. We offer a wide range of landscaping services, including hardscaping, irrigation, lighting, and more, and we use only the highest quality materials and techniques to ensure your satisfaction. Contact us today to schedule a consultation and transform your outdoor space. Landscaping Puyallup, Washington #landscapingPuyallup #LandscapeandDesign #Tran’sLandscaping #Washington submitted by Trans_Landscaping to u/Trans_Landscaping [link] [comments] |
2023.05.29 17:46 waitinonit C# app1.exe Requires app1.dll
I'm an occasional C# programmer who generally writes console applications for things like processing excel files (budget, asset tracking ...) and other sort of "quick hitter" utilities.
Recently I developed one such application (call it app1) that utilized the DateTime struct. I was using MSVS 2022 V17.5.4 with .Net 4.8.0.4084 under Windows10. This generated an exe and it worked as as expected.
Then I realized the DateOnly struct would be useful. It requires .NET 6. After some searching the web, I upgraded the project using the Upgrade Assistant Visual Studio extension. The Application>General>Target framework is now set to .Net 6.0.
The App.config file contains the following:
After I did that I was able to use the DateOnly struct and the program worked as expected. When I built the Release and moved the file app1.exe to the working directory I tried to run it.
The console window told me it couldn't find app1.dll. If I include app1.dll in the working directory things work as expected.
Prior to upgrading the project the file app1.exe was suitable for execution without requiring app1.dll.
I'll probably have to better understand how .Net works, which I will follow up on.
But for now, would someone be able to explain why my app1.exe file now requires app1.dll? As I mentioned, this wasn't the case prior to the upgrade.
submitted by
waitinonit to
csharp [link] [comments]
2023.05.29 17:46 NearbyNoise8652 Dysphoria (possible trigger warning)
35 AMAB, married, with two beautiful daughters, and about a year ago I discovered I was at odds with my gender assigned at birth and have been subsequently diagnosed with gender dysphoria after exploring my concerns in depth with my psychologist.
This past year I have explored various methods to alleviate gender dysphoria, including mindfulness training, positive affirmations, and self-acceptance courses. Despite my best efforts, I have come to the realization that these methods, including attempting to “think” my way out of my gender dysphoria, have not been serving me well.
One aspect that has been particularly challenging is the disconnection I have from my body. I struggle to fully connect with it and find respect or liking for it. I don't necessarily despise my body, I would just much prefer to have a female body. (Dysphoria for me is a sadness, a sustained sense of hopelessness reminding me I can't have the body I long for). I do however experience euphoria when I wear dresses, makeup etc. That may seem reasonably inert detail, but the fact dysphoria hasn’t manifested in outright hatred towards my body that you so often hear is the case, really compounds to the confusion around justifying the pursuit of hormone therapy, as you'll soon read.
I have experienced a loss of libido and difficulties with sexual satisfaction since discovering I had gender incongruity issues. I found temporary relief from all dysphoria after climaxing, sometimes lasting hours, and this lead me to convince myself that there were perhaps alternative motivations at play or at least hope of alternative ways to disprove or overcome dysphoria. However, after a lot of internalizing and journaling, it occurred to me that it’s actually more likely that the medical professionals are correct in their diagnosis. And my gender, and feelings towards, is probably completely beyond my control. And importantly, that these moments of relief are fleeting, meaningless, and arguably counterproductive as they result in false narratives, so I'm now learning to challenge the thoughts associated with experiencing sudden relief. That flip has been a big step for me, considering I used to spend my mental energy to challenge the dysphoric and euphoric feelings.
Until recently, I've viewed medical transition as being in direct competition with my values. I've really struggled with the notion that my "selfish wants / desires", are somehow getting the better of me, causing me to constantly think about about transitioning.
But I'm finding that I keep arriving at the same conclusion: I am a woman. I am a woman despite my doubts. I am a woman despite my fears. I can't change it. I can't control it, nor can my ambitions, my past achievements, my family. I simply am. I'm not broken. It's not going to "go away". It's not going to change. I might have reached out to the medical staff first, but I'm the last to the party. I need to learn to accept it. Embrace it. And this realization has provided me with a profound sense of clarity amidst the confusion and doubts, as it seems to provide an elegant answer to all of the seemingly irrational and selfish prospects transitioning has, in a way that suppression and ignoring couldn't ever do.
However this newfound clarity has also made me acutely aware of it’s implications. Though it pains me to say (there are some major potential relationship implications here), I have to face the very real possibility that the only viable way forward to live authentically is through medical transitioning, encompassing hormone therapy and potentially surgical interventions. However, despite this understanding, I find myself lacking the inner strength and conviction to make the decision to transition of my own accord.
As indicated earlier, my hesitations and fears of transitioning are largely intertwined with the concern for my marriage, as I fear that fully embracing my true self through transitioning might jeopardize the relationship with my spouse, whom I love deeply.
I don’t know what I expected from medical staff when I received my diagnosis, but I had to call my GP and struggle to get an appointment and request a GAHT consultation just to ask some questions around medical transition. I ended up pulling out during my second appointment for a variety of reasons, chief among them, was that it very much felt like it was my choice to start on hormones, if I want to. I didn’t chose any of this, nor do I want to "choose" to prescribe myself hormones knowing it can really mess things up for me.
I, like most people, respect and carry out medical directives given by medical professionals. And since they had established persistent dysphoria and they had my psychologist report, since they knew how easy I find it to discount my feelings, and surpress, I really feel it would have been more appropriate for them to firmly prescribe me with the most effective known treatment, GAHT, akin to how they have prescribed literally any other prescription for every other ailment I have had, and of course it would be a personal (though not recommended) choice NOT to take the hormones, as it is with any treatment. Rather than frame it as an option I could "chose".
But IANAD, and so I struggle with the prospect of actively “choosing” a treatment that may have significant consequences for my personal life. And as a result, I walked.
I’m at a loss with all this. I’ve been contemplating the role of mindfulness training and self-acceptance in alleviating gender dysphoria. One of the gender affirming care avenues outlined in my psych report suggests that mindfulness training can help disregard negative thoughts and promote self-acceptance. But I’m curious about the actual evidence supporting the effectiveness of mindfulness training in managing gender dysphoria. Are there any studies or research that demonstrate its impact on alleviating gender dysphoria or promoting well-being in individuals who choose not to transition medically?
I consider myself to be of average intelligence, and problem solving ability, and thus most of my thinking needs some degree of contemplating, validating and meditation. I find it challenging to comprehend how mindfulness and self-acceptance alone, without transitioning, can sufficiently address the distress and disconnect associated with gender dysphoria, assuming my experience is fairly typical.
For me, I can’t even reliably identify what thoughts are negative anymore, take my thoughts around the relief I had after sex for example - they seemed hopeful, and therefore positive - a lead to follow, but now I’m learning that they’re misguided and destructive.
I’m here for exploring alternative strategies that would both preserve my marriage and allow me to grow in self acceptance, but I’ve arrived at the same realization from multiple angles that there is just no substitute to taking real steps to align oneself with ones gender – in my experience its appears to be predetermined, or at least, not driven by choice or logic.
I’m interested in hearing insights anecdotal or otherwise, of evidence of individuals successfully utilizing mindfulness training or self-acceptance as an alternative to transitioning.
submitted by
NearbyNoise8652 to
TransLater [link] [comments]
2023.05.29 17:46 kazuhottie How do you guys handle hecarim in your games?
Hecarim is a champ i just cant deal with if they're not really far behind or i'm far ahead. Even early he can just run at me as jungle with ghost and whatever, and when he gets youmuu's, i'll see him for one second before i just get one shot. With purple, even if i do manage to root him, i find if i am even in range to be able to root him, i'm not surviving anyway. Is there anything i can do or is just more team reliant than other champs.
submitted by
kazuhottie to
ApheliosMains [link] [comments]
2023.05.29 17:45 SneneokNeok Countless rolls and 4 decent bows later, I finally have a god roll!
2023.05.29 17:45 Jared_Harbert Swimming Pool Renovation in Florida: Enhancing Your Pool's Beauty and Functionality
| Swimming pools are a popular feature of many homes in Florida, providing a refreshing escape from the heat and a place to relax and unwind. Over time, however, pools may start to show signs of wear and tear, requiring renovation to restore their beauty and functionality. This article will explore the importance of swimming pool renovation, the process of hiring a professional pool builder in Jacksonville, and the benefits of working with a swimming pool contractor. Swimming Pool Renovation Importance of Swimming Pool Renovation Enhancing Aesthetics and Functionality One of the key reasons to consider renovating your swimming pool is to enhance its aesthetics and functionality. Over the years, styles and trends change, and what was once considered modern and attractive may now appear outdated. Renovation allows you to update the look of your pool, incorporating new materials, finishes, and features to create a more visually appealing and enjoyable space. Ensuring Safety and Compliance Another crucial aspect of pool renovation is ensuring safety and compliance with current regulations. Safety standards evolve over time, and your pool may no longer meet the required guidelines. Renovation provides an opportunity to address any safety concerns, such as installing updated fencing, improving lighting, or upgrading filtration systems, to ensure a safe swimming environment for you and your loved ones. Increasing Property Value A well-maintained and renovated swimming pool can significantly increase the value of your property. When potential buyers or renters see a beautifully renovated pool, it adds to the overall appeal of the property. Renovating your pool not only enhances your enjoyment but also becomes a valuable investment that can yield returns in the future. Hiring a Professional Pool Builder in Jacksonville Researching Pool Builders When it comes to renovating your swimming pool, it's crucial to hire a professional pool builder with experience in handling renovation projects. Start by researching pool builders in Jacksonville who specialize in pool renovations. Look for companies with a strong reputation, positive customer reviews, and a portfolio of successful pool renovation projects. Checking Credentials and Experience Before finalizing a pool builder, check their credentials and experience. Ensure they hold the necessary licenses and certifications required by the state of Florida. A reputable pool builder will have a team of skilled professionals with expertise in pool renovations. Evaluating Previous Projects To gain confidence in their capabilities, evaluate the pool builder's previous renovation projects. Look for testimonials or before-and-after photos that showcase their work. This will give you a sense of their attention to detail, quality of craftsmanship, and ability to transform pools. Understanding the Renovation Process Assessment and Design The renovation process typically begins with an assessment of your existing pool and a consultation to discuss your renovation goals. A pool designer will work with you to create a design plan that incorporates your vision, functionality requirements, and budget. Demolition and Construction Once the design is finalized, the renovation process moves on to demolition, where any necessary removals or modifications are made. This could involve removing outdated or damaged materials, reconfiguring the pool layout, or expanding the pool size. Construction follows, including structural work, plumbing, and electrical installations. Plumbing and Electrical Considerations During pool renovation, it's essential to address any plumbing or electrical issues. Upgrading plumbing lines, pumps, and filters can improve the efficiency and performance of your pool. Similarly, updating electrical systems ensures proper functionality and adherence to safety standards. Finishing Touches and Landscaping As the renovation nears completion, attention shifts to the finishing touches. This includes selecting new pool finishes, tiles, coping, and decking options that align with your desired aesthetic. Landscaping around the pool area can also enhance the overall appeal and create a harmonious outdoor space. Cost Factors and Budgeting Materials and Equipment The cost of swimming pool renovation depends on various factors, including the materials and equipment used. Higher-quality materials, such as premium tiles or custom finishes, will contribute to a higher budget. Additionally, if your renovation involves incorporating new features like waterfalls, slides, or spas, the cost will increase accordingly. Pool Size and Complexity The size and complexity of your pool renovation project will significantly impact the overall cost. Larger pools require more materials and labor, increasing the budget. Similarly, if your pool has unique features or intricate designs, additional expertise and time will be required, affecting the cost. Additional Features and Upgrades When renovating your pool, you may want to consider adding extra features or upgrades. This could include energy-efficient equipment, automation systems, or LED lighting. While these additions can enhance the functionality and enjoyment of your pool, they will contribute to the overall cost. Expertise and Knowledge One of the primary benefits of hiring a swimming pool contractor for your renovation project is their expertise and knowledge. They understand the complexities involved in pool renovations and can provide valuable insights and recommendations based on their experience. A professional contractor will ensure that your renovation is executed efficiently and to the highest standards. Efficient Project Management Renovating a swimming pool involves coordinating multiple tasks and trades, such as demolition, construction, plumbing, and electrical work. A swimming pool contractor manages the project from start to finish, ensuring smooth communication between different teams and timely completion of each phase. This saves you the hassle of organizing and overseeing every aspect of the renovation. Warranty and Support Working with a reputable swimming pool contractor offers the advantage of warranties and post-renovation support. If any issues arise after the completion of the renovation, the contractor will address them promptly and efficiently. This provides peace of mind and ensures that you can enjoy your renovated pool without worrying about potential problems. Conclusion Swimming pool renovation in Florida is a significant investment that can enhance the beauty, functionality, and value of your pool. By hiring a professional pool builder in Jacksonville, you can benefit from their expertise, efficient project management, and access to quality materials. Remember to consider your budget, prioritize safety, and explore additional features that can elevate your pool experience. Enjoy the process of transforming your pool into a stunning oasis that provides enjoyment for years to come. FAQs 1. How long does a pool renovation typically take? The duration of a pool renovation varies depending on the complexity of the project. Minor renovations may take a few weeks, while more extensive renovations can take several months. A reputable pool builder will provide you with a timeline based on your specific renovation requirements. 2. Can I renovate my pool myself? Renovating a swimming pool is a complex task that requires specialized knowledge and expertise. It is recommended to hire a professional pool builder who has experience in pool renovations. They possess the necessary skills and equipment to ensure a successful and safe renovation. 3. What are some popular pool renovation trends? Some popular pool renovation trends include incorporating natural stone or mosaic tiles, adding water features such as waterfalls or fountains, integrating energy-efficient equipment, and creating a seamless transition between the pool and outdoor living spaces. 4. How much does it cost to renovate a swimming pool? The cost of pool renovation varies depending on factors such as the size of the pool, the extent of renovations, the materials used, and additional features. It is best to consult with a pool builder to get an accurate estimate based on your specific renovation goals. 5. Are there any maintenance requirements after pool renovation? After pool renovation, regular maintenance is essential to keep your pool in optimal condition. This includes routine cleaning, checking water chemistry, maintaining proper water levels, and servicing equipment as needed. Your pool builder or contractor can provide guidance on post-renovation maintenance to ensure the longevity of your pool. submitted by Jared_Harbert to u/Jared_Harbert [link] [comments] |
2023.05.29 17:45 NearbyNoise8652 Dysphoria (possible trigger warning)
35 AMAB, married, with two beautiful daughters, and about a year ago I discovered I was at odds with my gender assigned at birth and have been subsequently diagnosed with gender dysphoria after exploring my concerns in depth with my psychologist.
This past year I have explored various methods to alleviate gender dysphoria, including mindfulness training, positive affirmations, and self-acceptance courses. Despite my best efforts, I have come to the realization that these methods, including attempting to “think” my way out of my gender dysphoria, have not been serving me well.
One aspect that has been particularly challenging is the disconnection I have from my body. I struggle to fully connect with it and find respect or liking for it. I don't necessarily despise my body, I would just much prefer to have a female body. (Dysphoria for me is a sadness, a sustained sense of hopelessness reminding me I can't have the body I long for). I do however experience euphoria when I wear dresses, makeup etc. That may seem reasonably inert detail, but the fact dysphoria hasn’t manifested in outright hatred towards my body that you so often hear is the case, really compounds to the confusion around justifying the pursuit of hormone therapy, as you'll soon read.
I have experienced a loss of libido and difficulties with sexual satisfaction since discovering I had gender incongruity issues. I found temporary relief from all dysphoria after climaxing, sometimes lasting hours, and this lead me to convince myself that there were perhaps alternative motivations at play or at least hope of alternative ways to disprove or overcome dysphoria. However, after a lot of internalizing and journaling, it occurred to me that it’s actually more likely that the medical professionals are correct in their diagnosis. And my gender, and feelings towards, is probably completely beyond my control. And importantly, that these moments of relief are fleeting, meaningless, and arguably counterproductive as they result in false narratives, so I'm now learning to challenge the thoughts associated with experiencing sudden relief. That flip has been a big step for me, considering I used to spend my mental energy to challenge the dysphoric and euphoric feelings.
Until recently, I've viewed medical transition as being in direct competition with my values. I've really struggled with the notion that my "selfish wants / desires", are somehow getting the better of me, causing me to constantly think about about transitioning.
But I'm finding that I keep arriving at the same conclusion: I am a woman. I am a woman despite my doubts. I am a woman despite my fears. I can't change it. I can't control it, nor can my ambitions, my past achievements, my family. I simply am. I'm not broken. It's not going to "go away". It's not going to change. I might have reached out to the medical staff first, but I'm the last to the party. I need to learn to accept it. Embrace it. And this realization has provided me with a profound sense of clarity amidst the confusion and doubts, as it seems to provide an elegant answer to all of the seemingly irrational and selfish prospects transitioning has, in a way that suppression and ignoring couldn't ever do.
However this newfound clarity has also made me acutely aware of it’s implications. Though it pains me to say (there are some major potential relationship implications here), I have to face the very real possibility that the only viable way forward to live authentically is through medical transitioning, encompassing hormone therapy and potentially surgical interventions. However, despite this understanding, I find myself lacking the inner strength and conviction to make the decision to transition of my own accord.
As indicated earlier, my hesitations and fears of transitioning are largely intertwined with the concern for my marriage, as I fear that fully embracing my true self through transitioning might jeopardize the relationship with my spouse, whom I love deeply.
I don’t know what I expected from medical staff when I received my diagnosis, but I had to call my GP and struggle to get an appointment and request a GAHT consultation just to ask some questions around medical transition. I ended up pulling out during my second appointment for a variety of reasons, chief among them, was that it very much felt like it was my choice to start on hormones, if I want to. I didn’t chose any of this, nor do I want to "choose" to prescribe myself hormones knowing it can really mess things up for me.
I, like most people, respect and carry out medical directives given by medical professionals. And since they had established persistent dysphoria and they had my psychologist report, since they knew how easy I find it to discount my feelings, and surpress, I really feel it would have been more appropriate for them to firmly prescribe me with the most effective known treatment, GAHT, akin to how they have prescribed literally any other prescription for every other ailment I have had, and of course it would be a personal (though not recommended) choice NOT to take the hormones, as it is with any treatment. Rather than frame it as an option I could "chose".
But IANAD, and so I struggle with the prospect of actively “choosing” a treatment that may have significant consequences for my personal life. And as a result, I walked.
I’m at a loss with all this. I’ve been contemplating the role of mindfulness training and self-acceptance in alleviating gender dysphoria. One of the gender affirming care avenues outlined in my psych report suggests that mindfulness training can help disregard negative thoughts and promote self-acceptance. But I’m curious about the actual evidence supporting the effectiveness of mindfulness training in managing gender dysphoria. Are there any studies or research that demonstrate its impact on alleviating gender dysphoria or promoting well-being in individuals who choose not to transition medically?
I consider myself to be of average intelligence, and problem solving ability, and thus most of my thinking needs some degree of contemplating, validating and meditation. I find it challenging to comprehend how mindfulness and self-acceptance alone, without transitioning, can sufficiently address the distress and disconnect associated with gender dysphoria, assuming my experience is fairly typical.
For me, I can’t even reliably identify what thoughts are negative anymore, take my thoughts around the relief I had after sex for example - they seemed hopeful, and therefore positive - a lead to follow, but now I’m learning that they’re misguided and destructive.
I’m here for exploring alternative strategies that would both preserve my marriage and allow me to grow in self acceptance, but I’ve arrived at the same realization from multiple angles that there is just no substitute to taking real steps to align oneself with ones gender – in my experience its appears to be predetermined, or at least, not driven by choice or logic.
I’m interested in hearing insights anecdotal or otherwise, of evidence of individuals successfully utilizing mindfulness training or self-acceptance as an alternative to transitioning.
submitted by
NearbyNoise8652 to
asktransgender [link] [comments]
2023.05.29 17:44 Hodl4success Ladies PLEASE stop!
Men are the provider is being wrongly misinterpreted, as to men are our personal 🐷 bank!
It’s insane how a lot of women (esp younger generation) are so hooked on men being the provider. Which I’m okay with. BUT they are taking it way out of context. That doesn’t mean the man PAYS for 100% of everything and you just sit on your stack up all your money.
There’s also a thing called (helpmate), which is your role in a traditional relationship. It’s crazy how a lot of women are only picking traditional values/qualities that benefit them. But when it’s time to doing your part… you scream “that’s struggle love”.
Stop misinterpreting what struggle love means. There’s nothing wrong with helping your man out. I’m not saying it HAVE to be 50:50. But it’s a minority of relationships/households, where the man pays for 💯 of EVERYTHING in today’s society (not excluding trips/hainails/trips/shopping). I’m not saying there’s not men who are able/currently doing that. But it’s definitely not the majority or even near 50% of men. Especially when you factor in kids!
Before you come in here and misconstrue what I’m trying to convey. I’m not saying you should be with a man who doesn’t have his stuff in order (roof over his head, car, stabled income, decent credit, and etc). That’s NOT what I’m advocating. But 🛑 saying there’s no good men out here. It’s not that there’s no good men, we just don’t want to get f*** financially by our woman. We already getting f**** by Uncle Sam, our jobs, and life.
I’m all for treating a woman out, massages, good food, gifts, trips together, spontaneous activities and etc. But damn… we not the federal reserve. We can’t just print money out of thin air.
I understand back in the day it was more feasible for the man to provide everything. But times are WAY different today, there’s a thing called COST OF LIVING/INFLATION. It’s not that men don’t want to provide and are just losers. The market is NOT the same anymore.
The chances of majority women finding a high earning man ($6 figures or more) is impossible. Cause there’s a small % of men who even make that much. That’s not even factoring in if they are already married/compatibility/etc.
Why would you want to overburden a man with such financial responsibilities, especially when you are already working as well. If a man is paying the rent/or mortgage, utilities, miscellaneous stuff… the least you can do is pull your weight as well. That alone is more than 70% of your living expenses (we haven’t even factored in daycare/other childcare expenses). What’s wrong with you buying food, paying your car note (most likely had that car loan prior to even meeting him), phone, and your personal self care (you should be doing that regardless if you’re in a relationship). If your man does extra outside of that, that’s a bonus. But it shouldn’t be a monthly obligation.
Please 🛑.
*Before you comment that us men need to stop looking for these type of women. These type of women are EVERYWHERE (If you aren’t one of these type of women this post isn’t for you). It’s not just women who still live with their parents. It’s single women, single moms, blue collar, white collar, and etc. They’re everywhere 😂. It’s a damn epidemic 😆.
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2023.05.29 17:43 NearbyNoise8652 Dysphoria and treatment
35 AMAB, married, with two beautiful daughters, and about a year ago I discovered I was at odds with my gender assigned at birth and have been subsequently diagnosed with gender dysphoria after exploring my concerns in depth with my psychologist.
This past year I have explored various methods to alleviate gender dysphoria, including mindfulness training, positive affirmations, and self-acceptance courses. Despite my best efforts, I have come to the realization that these methods, including attempting to “think” my way out of my gender dysphoria, have not been serving me well.
One aspect that has been particularly challenging is the disconnection I have from my body. I struggle to fully connect with it and find respect or liking for it. I don't necessarily despise my body, I would just much prefer to have a female body. (Dysphoria for me is a sadness, a sustained sense of hopelessness reminding me I can't have the body I long for). I do however experience euphoria when I wear dresses, makeup etc. That may seem reasonably inert detail, but the fact dysphoria hasn’t manifested in outright hatred towards my body that you so often hear is the case, really compounds to the confusion around justifying the pursuit of hormone therapy, as you'll soon read.
I have experienced a loss of libido and difficulties with sexual satisfaction since discovering I had gender incongruity issues. I found temporary relief from all dysphoria after climaxing, sometimes lasting hours, and this lead me to convince myself that there were perhaps alternative motivations at play or at least hope of alternative ways to disprove or overcome dysphoria. However, after a lot of internalizing and journaling, it occurred to me that it’s actually more likely that the medical professionals are correct in their diagnosis. And my gender, and feelings towards, is probably completely beyond my control. And importantly, that these moments of relief are fleeting, meaningless, and arguably counterproductive as they result in false narratives, so I'm now learning to challenge the thoughts associated with experiencing sudden relief. That flip has been a big step for me, considering I used to spend my mental energy to challenge the dysphoric and euphoric feelings.
Until recently, I've viewed medical transition as being in direct competition with my values. I've really struggled with the notion that my "selfish wants / desires", are somehow getting the better of me, causing me to constantly think about about transitioning.
But I'm finding that I keep arriving at the same conclusion: I am a woman. I am a woman despite my doubts. I am a woman despite my fears. I can't change it. I can't control it, nor can my ambitions, my past achievements, my family. I simply am. I'm not broken. It's not going to "go away". It's not going to change. I might have reached out to the medical staff first, but I'm the last to the party. I need to learn to accept it. Embrace it. And this realization has provided me with a profound sense of clarity amidst the confusion and doubts, as it seems to provide an elegant answer to all of the seemingly irrational and selfish prospects transitioning has, in a way that suppression and ignoring couldn't ever do.
However this newfound clarity has also made me acutely aware of it’s implications. Though it pains me to say (there are some major potential relationship implications here), I have to face the very real possibility that the only viable way forward to live authentically is through medical transitioning, encompassing hormone therapy and potentially surgical interventions. However, despite this understanding, I find myself lacking the inner strength and conviction to make the decision to transition of my own accord.
As indicated earlier, my hesitations and fears of transitioning are largely intertwined with the concern for my marriage, as I fear that fully embracing my true self through transitioning might jeopardize the relationship with my spouse, whom I love deeply.
I don’t know what I expected from medical staff when I received my diagnosis, but I had to call my GP and struggle to get an appointment and request a GAHT consultation just to ask some questions around medical transition. I ended up pulling out during my second appointment for a variety of reasons, chief among them, was that it very much felt like it was my choice to start on hormones, if I want to. I didn’t chose any of this, nor do I want to "choose" to prescribe myself hormones knowing it can really mess things up for me.
I, like most people, respect and carry out medical directives given by medical professionals. And since they had established persistent dysphoria and they had my psychologist report, since they knew how easy I find it to discount my feelings, and surpress, I really feel it would have been more appropriate for them to firmly prescribe me with the most effective known treatment, GAHT, akin to how they have prescribed literally any other prescription for every other ailment I have had, and of course it would be a personal (though not recommended) choice NOT to take the hormones, as it is with any treatment. Rather than frame it as an option I could "chose".
But IANAD, and so I struggle with the prospect of actively “choosing” a treatment that may have significant consequences for my personal life. And as a result, I walked.
I’m at a loss with all this. I’ve been contemplating the role of mindfulness training and self-acceptance in alleviating gender dysphoria. One of the gender affirming care avenues outlined in my psych report suggests that mindfulness training can help disregard negative thoughts and promote self-acceptance. But I’m curious about the actual evidence supporting the effectiveness of mindfulness training in managing gender dysphoria. Are there any studies or research that demonstrate its impact on alleviating gender dysphoria or promoting well-being in individuals who choose not to transition medically?
I consider myself to be of average intelligence, and problem solving ability, and thus most of my thinking needs some degree of contemplating, validating and meditation. I find it challenging to comprehend how mindfulness and self-acceptance alone, without transitioning, can sufficiently address the distress and disconnect associated with gender dysphoria, assuming my experience is fairly typical.
For me, I can’t even reliably identify what thoughts are negative anymore, take my thoughts around the relief I had after sex for example - they seemed hopeful, and therefore positive - a lead to follow, but now I’m learning that they’re misguided and destructive.
I’m here for exploring alternative strategies that would both preserve my marriage and allow me to grow in self acceptance, but I’ve arrived at the same realization from multiple angles that there is just no substitute to taking real steps to align oneself with ones gender – in my experience its appears to be predetermined, or at least, not driven by choice or logic.
I’m interested in hearing insights anecdotal or otherwise, of evidence of individuals successfully utilizing mindfulness training or self-acceptance as an alternative to transitioning.
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2023.05.29 17:43 The_HatedOne Daniel Micay steps down as the leader of GrapheneOS. My thoughts and why you should keep using it.
Daniel Micay, the founder and long-time lead developer of GrapheneOS, has
recently stepped down from the position of lead developer and will also be stepping down as a director of the GrapheneOS foundation. These announcements coincided with a video made by Louis Rossman where he suggested he would be leaving GrapheneOS due to Daniel Micay's communication issues.
There are important takeaways that a lot of people are missing and some very damaging and outright manipulative 'privacy advice' that stemming from this situation that needs to be called out. So here we go.
Daniel Micay stepping down is a good thing
I think this is very positive news both for Micay and the GrapheneOS project. Daniel Micay's security expertise and mobile engineering skills have been unmatched. In this regard, he is truly a world-class expert that was able to deliver the most secure operating system in the world and build up a team of talented developers that followed his vision. He did this from scratch, without the help from big investors or even big salaries. GrapheneOS has been funded by voluntary donations and it is that much more amazing that it became such a polished and easy-to-use product.
GrapheneOS today is full team of security experts and developers working to enhance privacy and security of everyone at zero cost to the end user. GrapheneOS is now a properly institutionalized entity. Having incorporated as a non-profit foundation, it's now broadly recognized not just in the infosec and privacy communities, but also in the broader technology sphere. It has received an endless amount of publicity and media attention and will be receiving even more in the future. This will be good both for talent acquisition and future fundraising campaigns. Daniel Micay deserves praise for his achievements in this regard and I will be grateful for delivering us the most important privacy project of my lifetime.
That being said, Daniel has been struggling with public communication and often ended up in up stirred up drama much of which probably could have been avoided if it was handled by a professional PR team, instead of Micay. There has been countless of examples of this and while it did highlight the negative aspects of toxicity in privacy communities, it also didn't serve to portray Micay as the best communicator either. I think it is positive news both for Micay and the GrapheneOS project that he is stepping down and will no longer play a role in public relations of the project. I hope Micay will find the recovery he is looking for and I wish the GrapheneOS project all the success it 100% deserves.
The Rossmann drama and why you should still use GrapheneOS
Louis Rossmann, a popular YouTube and a vocal advocate for the right to repair, has made several videos praising and recommending GrapheneOS.
In his most recent video, however, Daniel Micay is seen pressuring Rossmann into deleting a comment he left underneath one of Techlore's videos on Daniel Micay and the GrapheneOS community. In no honest interpretation can someone argue that Rossmann would want to bully or harass Micay, yet that was Micay's insinuation in his pressure on Rossman. Many have jumped to making conclusions on Micay's mental health and the validity of the GrapheneOS project as a whole and this is where I think Rossmann overstepped in his logic. In Rossmann's conclusion, he lost trust in GrapheneOS if it is run by Micay because of his behavior. I understand why someone would make that assumption on the emotional level but it is completely illogical and removed from what's possible in reality.
GrapheneOS or anyone working on the project, cannot hijack your installation. They don't have access to the kind of data they'd need in order to discern individual users.
GrapheneOS doesn't collect device identifiers, IMSI numbers or phone numbers. GrapheneOS doesn't require any user account like you'd need with the stock Android or the iPhone/iOS. The only relevant information collected by GrapheneOS is the IP address, which can be easily obfuscated with a VPN or Tor, both of which work 100% and have no issues connecting to GrapheneOS servers.
GrapheneOS purges all IP logs within 10 days. The only other data point is the device model, .e.g. "Pixel 6". But that isn't narrow enough to discern individual users. In other words, GrapheneOS would never know who you are as a user of the system.
I am saying this, because a lot of people for so many years have tried to try to discredit GrapheneOS both as a project and as a product because of issues they have with Micay or other personalities. This is a completely illogical and asinine assumption. It has been made by Techlore, Rossmann and many others I find it very harmful to suggest objectively inferior privacy solutions because of personal feuds.
I get it that drama sucks. But let's keep our privacy recommendations based on merit rather our emotions and personal perceptions. GrapheneOS is objectively the most private and secure option out there. There really isn't any other operating system that comes close. Not CalyxOS, not LineageOS, not stock Android nor iOS.
I have made a video on GrapheneOS security and
I interviewed one of their developers. But if you want to hear it from a source I have 0 connections to, check out
this comparision between GrapheneOS and CalyxOS. Whatever you think of Micay or anyone involved has zero value on the technical merit of GrapheneOS.
TL;DR
GrapheneOS is a world-class team of security experts and developers who working for the non-profit to develop the most secure operating system in the world. Despite personal and emotional issues with some individuals, it is by every merit the most trusted, private and secure system and it is the only one that should be recommended for privacy conscious users. No amount of drama can change this reality. Only merit can.
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2023.05.29 17:42 OniiChan8723 H: non meta commandos W: offers
2023.05.29 17:42 DERtheBEAST Hemophoria
I'm a bleeding heart romantic A little too intense When I'm feeling frantic Thoughts can make no sense
What will you find Given enough time Under paper skin How soon till I begin To wear you down, my heart Never listened from the start Searching for its own kind Making up its mind, I'm Left to question why It's you, I can't deny When I wished that I was dead Well, I wanted you instead Cannot forget what you said Words that live inside my head
A spectre of, a lost love Part of me so deep Awakened as I came undone Now these feelings won't retreat Have I become, the monster and the beast Succumb to numb, admit defeat Turn off this bloody chunk of meat
Been writing as a hobby for years, mostly when stuck in my head or feeling extreme. Recently had good experiences with sharing more so I'm hoping someone finds some value in this. I have tons of these saved and want to do something with them. If you got this far, you are awesome and have a great day!
Edit: Mobile formatting
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2023.05.29 17:42 jaysornotandhawks 2023 IIHF Men's World Rankings (full chart!), and 2026 Olympic starting points
Source:
IIHF.
You won't understand this post unless you understand how the IIHF World Rankings work. Perhaps later today or this week I'll put out a post on how the rankings work, so that I can keep linking back to it rather than having to explain it every year. Also, Another post about the Women's World Ranking will be put out after their last tournament - Division 1A - is completed in August. Women's Olympic qualification starting points are decided at the end of next year. The 2023 Men's IIHF season is now over! We now know the official rankings of each team.
Point Values:
Tournament | 2022 Ranking Value | 2023 Ranking Value |
2023 Worlds | | 100% |
2022 Worlds | 100% | 75% |
2022 Olympics | 100% | 75% |
2021 Worlds | 75% | 50% |
2020 Worlds | 50% | 25% |
2019 Worlds | 25% | |
For the cancelled 2020 tournament, points were given based on seed. For 2021, where every division except the top level was cancelled, points were given based on Pre-Championship Report ranking. Below is the table that includes each team's ranking from this year as well as last year, and the points earned in each individual year.
I've also included a column for Olympic seed, to see who starts where for Olympic qualifying.
- Olympic seeds given here assume that every country who is eligible to participate, does.
- Where a country chooses not to participate or where they cannot participate, everyone ranked below them moves up.
Final 2023 IIHF Men's World Rankings: Final 2023 IIHF Men's World Rankings, top 37 countries Final 2023 IIHF Men's World Rankings, countries 38-58 Notes: - This year, there was a slight change: The gold medallist now gets 1600 points instead of 1200, with all gaps between each placement remaining the same (1560 for silver etc). This is to allow for new teams to join at the bottom.
- As in previous years, Russia and Belarus were given points based on their ranks in the Pre-Championship Report.
- I cannot yet prove this, but Georgia appears to have been disqualified from Division 2A (if I had to guess, likely due to the use of ineligible players). This, along with North Korea's withdrawal from Division 3A, gives both countries 0 points for this year. Both are also relegated.
And with these rankings, we now see who starts where for Olympic qualifying! In this post, I'm only going to include the final round of qualification as well as the main Olympic tournament.
- In this section, numbers in parentheses given are Olympic seeds, NOT World Ranking.
- This assumes the IOC upholds the bans of Russia and Belarus.
Projected Final Round of Men's Olympic Qualification: Each group is hosted by the top seed. Group D: | Group E: | Group F: |
(9) Latvia | (10) Denmark | (11) Norway |
(14) Austria | (13) Kazakhstan | (12) France |
(15) Slovenia | (16) Hungary | (17) Great Britain |
Qualifier 6 | Qualifier 5 | Qualifier 4 |
Qualifiers 4-6 are determined by the teams who finish first in their respective groups in the Third Round of Qualification. The winners of these three groups will advance as Qualifier 1, Qualifier 2 and Qualifier 3, in the order that they are ranked in the World Ranking (
i.e. the highest advancing seed would be Qualifier 1, while the lowest is Qualifier 3). These three teams advance to the...
Men's Olympic Tournament 2026 (Projected Groups): Group A: | Group B: | Group C: |
(1) Canada | (2) Finland | (3) USA |
(6) Switzerland | (5) Sweden | (4) Germany |
(7) Czechia | (8) Slovakia | Wild Card 1 |
Wild Card 4 | Wild Card 3 | Wild Card 2 |
... where Wild Cards 1-4 are Qualifier 1, Qualifier 2, Qualifier 3 and host Italy, in the order that they are ranked in the World Ranking (
written this way just in case someone ranked below Italy ends up qualifying).
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2023.05.29 17:42 AyyMz H: Quad 50VHC Stealth Railway W: Fasnacht Masks or Jumpsuits
2023.05.29 17:41 MinisterOfSmiles 27 [M4F] New Jersey/Anywhere - Seeking traditional romance with positive, fun-loving partner
Hello everyone, my name is
David - (here are some pictures of me) and I'm a 27-year-old computer science graduate from New Jersey. I'm here on reddit in the hopes of finding a like-minded woman who is interested in a great long-term relationship.
In my free time, I enjoy exploring the great outdoors through camping, going to Renaissance fairs and museums, skateboarding, taking walks on the beach, and trying new restaurants. I'm a big fan of gaming, both on my PC and Switch, and listening to Extreme Metal music, especially Black Metal, Death Metal, Brutal Death Metal, and Slam. I'm also slowly learning Japanese, not just for anime, but also for music and to have fun playing games in the original language (I've been going kinda slow but I have a long duolingo streak). Some of my favorite bands include: Cradle of Filth, Belphegor, Gorgoroth, Mayhem, Emperor, Imperial Circus Dead Decadence, Unlucky Morpheus, King Diamond, The Black Dahlia Murder, and Burzum.
In my search for a partner, I'm looking for someone who has a great sense of humor, strong family values, and a positive outlook on life. I prefer women between the ages of 18-24 who are East-Asian, South-East-Asian, or Caucasian, and who are slim, fit, or petite. While education and job aren't crucial to me, I'm not interested in someone who has had a lot of sexual partners. My main priority is finding someone who is interested in a serious relationship and starting a family someday.
If this sounds like you, I'd love to get to know you better. Don't hesitate to send me a message and let's see where things go! I'd love to get a photo as well.
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2023.05.29 17:41 jhpratt2 $nwbo-Pakistan
Currently, NWBO's Sawston plant is the only visible global hub for DC VAX L manufacturing and distribution (MHRA MIA approval 3/20/23) . For $400 , FED EX (
https://www.fedex.com/en-us/custom-critical.html) ships anywhere globally within the required timeframes.A SAGE (
https://journals.sagepub.com/doi/10.1177/20363613231179541) 5/26/23 scientific publication demonstrates intent by Pakistani neurosurgeons to treat and cure their GBM patients. Looks like the DC VAX L JAMA paper and LIAU- Bosch presentations since 10/26/22 have created global awareness that DCVAX L will be is a major global cell based biotech therapy, addressing GBM , and all solid tumors(
https://conferences.asco.org/am/industry-expert-theater).
With 50% of LIAU-SPORE-UCLA combo patents living 10 years, DC VAX L has turned SOC's GBM treatment from a terminal (16.5) months disease into a chronic treatable malignancy .
Dr. Greg Zivic:
"This treatment can turn a Glioblastoma into a chronic treatable disease even after recurrence of the tumor . "
https://nwbio.com/northwest-biotherapeutics-and-advent-bioservices-announce-receipt-of-license-for-commercial-manufacturing-at-sawston-u-k-facility/ https://twitter.com/AllenTurner206/status/1636426400382205952 https://investorshub.advfn.com/boards/read_msg.aspx?message_id=171479167 Monday, May 29, 2023 9:13:34 AM
Post# 596739 of 596755 4 Pakistani neurosurgeons endorsing the JAMA Liau dc vax l phase 3 study. Will the RA in Pakistan facilitate their patients' resected GBM tumors and lysate being sent to Sawston , with syringes of dc vax l sent back to Pakistan?
https://jamanetwork.com/journals/jamaoncology/fullarticle/2798847 https://journals.sagepub.com/doi/10.1177/20363613231179541 https://pubmed.ncbi.nlm.nih.gov/36591625/ IMO,BB's consultant is a "legend ", as alleged.Therefore, I recommend reading every on of his posts, word for word.
Bright Boy Brian F Egolf Sr M: Bright Boy
Re: ae kusterer post# 593171
Sunday, May 14, 2023 2:22:21 PM
Post# 593185 of 593185 I am definitely not a biotech expert and what I've learned about Northwest and DCVax-l was shared with me by one of the legends in the biotech world !!! My biggest takeaway is this:
From 2018 forward, it became apparent that DCVax-L was a breakthrough, technological process for the treatment of nGBM and rGBM, but its true potential was only known by a "handful" of experts, and as such, the understanding of the broader market implications was a relative unknown. Early on, several of the comments that I heard from BP were," The GBM market is really not that big!" and " Personalized, Immunotherapy vaccines are not really in our 'Wheelhouse'. We sell compounds/pills!!" On and on! The comments didn't mean that BP wasn't paying attention! Quite the contrary, BP was watching like a hawk as results from Dr. Liau and the UCLA trials began to leak into the medical community suggesting a broader application of DCVax-L on a "stand alone" basis and in combination with CI's for all large tumor cancers ( mentioned in the latest 10Q for future trials), thus dramatically expanding market potentials!!! But the "Big Moment" occurred in late October of last year when the STADIUM LIGHTS turned on, shining bright lights on the latest nGBM/rGBM ,Dr. Liau trial data suggesting 50%to 65% OS for 8 years with emphasis on rGBM !!! That was the point in time when BP and the entire biotech world realized that GBM/rGBM would be treated and managed as a CHRONIC DISEASE!!! with unlimited PROMISE and HOPE for patients and unlimited marketing potential to finance existing vaccine production and the continuing development for improved treatments for all diseases!!!!!
So that's what I learned and that's my story and I'm stickin to it!!!!
Cheers especially to all the Mom's and to everyone !!!
BB
Joseph H.Pratt:
https://investorshub.advfn.com/boards/read_msg.aspx?message_id=172010930 Bright Boy Re: None Saturday, March 18, 2023 12:38:55 PM Post# of 596750 Go People, People, People !!!!
The light switch just turned on for me !!! I'm not a doctor or scientist or a STEM concentration "rock star", but if I read something over and over again several times and look carefully at the pictures SOMETIMES, NOT ALL THE TIME, a major mental breakthrough occurs and I believe that I've discovered something very profound!!
In this case, I believe the main message from the slide deck is that DCVax-L, either by itself or in combination with CI's has turned the whole thing around for treating nGBM/rGBM from having to kill the tumor to a "management process" !! It looks like now with this new information, that GBM patients can receive vaccinations as needed with "Zero" side effects and live a long and happy life !!! A comment from a medical expert that DOES KNOW !!!:
Dr. Greg Zivic:
This treatment can turn a Glioblastoma into a chronic treatable disease even after recurrence of the tumor.
So help me out here. Does the above reasoning seem logical based on the slides all of us have just reviewed?? If it does or is, then little Team Northwest has just changed the healthcare landscape forever in the way that we treat disease!!!!!
Am I way off base or are all of onto to something that is fabulous beyond belief???
Cheers,
BB
Bright Boy Re: thermopost# 591947 Tuesday, May 09, 2023 8:41:30 PM Post# of 596749 Go The UK is determined to be the world carrousel for use of immunotherapy vaccines to treat cancers and all forms of disease!!! From my friends in the UK, my use of the word "determined" grossly understates the effort behind the "Grand Plan"!!
So far, the MHRA has not only accepted and approved the MIA application (manufacturing license), but voluntarily offered the expansion to a GLOBAL MANUFACTURING" license allowing for the import of live cells and the export of vaccines to the far corners of the earth!!! People!!! That is huge!!!!! BUT as always 99.99% of the retail investors don't understand the significance of that license or anything else about the process and look to the screen to validate the importance/value of the license, where they are greeted by Citadel and Virtu and the rest of the gang that manipulate the price to new lows, confirming that, in spite of everything they just read from the greatest medical minds in the universe, is a bunch of crap!!!!
Fortunately for the cancer patients and shareholders of Northwest, the MHRA does not include in their decision making process the current SP of NWBO or the opinion of the "gutter filth" that manage those companies or any other companies that participate in the ordered destruction of small biotechs that are engaged in the development of immunotherapy vaccines!! So, it's on to the filing of the MAA (marketing license), the approval and the decisions that will guarantee swift treatment deliveries to patients!!
So Griffin and Cifu and Fuerstein and the rest can lie all they want , but the GREAT UNITED KINGDOM will not be denied the ultimate crown of being the WORLD CENTER for CANCER TREATMENT !!!!!
Cheers,
BB
Bright Boy Re: hoffmann6383post# 578889 Tuesday, March 21, 2023 1:55:12 PM Post# of 596749 Go People, People, People!!! It's your friendly "hillbilly" here with some more great news!! Don't know if I can "one up" my earlier post about the "Dog eating the license", but I'll try. So here we go!!
I don't think everyone realizes how dynamic and important the manufacturing license really is so I'll take a shot at giving you my take on it. First of all, the marketing approval (MAA) and the government subsidy approval(NICE) are pretty much in the bag before the manufacturing team gets the "green light" to proceed. The MAA and NICE teams talk to the MIA team and say," This stuff looks really cool and we wanted to let you know before you run off and do a lot of work on something that we won't approve when you're finished!!" Okay! So that's the first part.
Now for the second part and this is the part that involves a lot of money so read very carefully!!! The MIA license allows for global export of the vaccines and global import of immune cells/tumor resected material. Anyone in the entire world that is diagnosed with GBM can NOW ship their tumor samples to Northwest/Advent/Sawston to have their personal vaccine made and stored, all to be shipped back to the patient/doctor on a prescribed injection schedule. The beauty of this process is that patients everywhere can NOW receive their vaccine on a compassionate care basis. No more waiting!! No more opportunities for the "dark forces" to delay or deny suffering cancer patients their desperately needed treatments !!!
People, as of yesterday, Northwest is now IN BUSINESS !!!! AND that opens the door for institutional investors and an uplist to the New York or Nasdaq exchanges!!!!
All of the above is as good as that first sip of ice cold buttermilk on a hot summer day!!!! AND for those unfortunate shorts and haters it adds a whole new description to the letters FTD and I'll let you guess what that might be!!!
Cheers,
BB
Bright Boy Re: None Tuesday, March 21, 2023 9:05:54 PM Post# of 596749 Go The MIA allows for "International Immune Cell Imports" and "International Vaccine Exports" !!! That is big news and a big, big market and should access every cancer patient in need!!!!
Cheers,
BB
ae kusterer
Re: None
Monday, May 29, 2023 9:13:34 AM
Post# 596739 of 596755 4 Pakistani neurosurgeons endorsing the JAMA Liau dc vax l phase 3 study. Will the RA in Pakistan facilitate their patients' resected GBM tumors and lysate being sent to Sawston , with syringes of dc vax l sent back to Pakistan?
https://jamanetwork.com/journals/jamaoncology/fullarticle/2798847 https://journals.sagepub.com/doi/10.1177/20363613231179541 https://pubmed.ncbi.nlm.nih.gov/36591625/ Abstract Objective: To define the landscape of treatment patterns and current epidemiological data regarding gliomas in Pakistan.
Methods: As part of the Pakistan Brain Tumour Epidemiology Study (PBTES), data were collected from 32 neurosurgical centres across the country. Our retrospective study looked at patients who underwent surgical procedures for gliomas in 2019 in neurosurgical centres. The data was collated and analysed using STATA version 15.
Results: A total of 781 patients with gliomas were identified 479(61.8%) in public sector hospitals, 302(39.1%) in the private sector). The most common histopathological subtypes were glioblastoma 262 (33.5%), followed by astrocytoma 147(18.8%) and oligodendroglioma 93(11.9%). Gender distribution was skewed towards men 508(65%). Private institution hospitals performed surgical biopsies as the first surgical procedure 75(23%) more often than public hospitals 38(9%). Chemotherapy was given to 115(29.8%) patients, and there was no data regarding 467(53%) of patients. Similarly, only 202(43.9%) patients received radiation therapy, and there was no data for 469(60%) of patients. For high-grade gliomas specifically, only 95(31.8%) patients with HGG have a record of receiving radiation therapy, and only 57(18.9%) had a record of being started on chemotherapy.
DCvax: A promising advancement in oncology for the treatment of glioblastoma Areeba Fareed
https://orcid.org/0000-0001-5906-9852 [email protected], Samia Rohail
https://orcid.org/0000-0003-1488-0080, […], and Abdul Moiz Khan
https://orcid.org/0000-0001-9796-8867+1View all authors and affiliations All Articles
https://doi.org/10.1177/20363613231179541 Contents Declaration of conflicting interests Funding ORCID iDs Footnotes References PDF / ePub More Dear Editor, Glioblastoma is a malignant neoplasm of the central nervous system that arises from glial cells, primarily astrocyctes and is characterized by poorly differentiated, fusiform, round or pleomorphic astrocyctic cells with marked nuclear atypical and brisk mitotic activity.1 Despite advances in early diagnosis and comprehensive treatments, there is nearly 100% recurrence rate and dismal patient survival.2 According to researchers, more than 13,000 Americans are diagnosed with Glioblastoma annually, causing significant morbidity and mortality. There has been no cure for Glioblastoma so far.3 Treatment options often include surgical removal of the tumor followed by concomitant radiation and adjuvant temozolomide TMZ chemotherapy which has been the standard of care for glioblastoma since decades, but exposure to high doses of ionizing radiation is a well-known exogenous risk factor for glioblastoma. The inability to cross the BBB is the major obstacle in achieving remission after surgical resection followed by chemotherapy and radiation.4 As a result, glioblastoma typically recurs within six to 8 months and the survival rate is generally less than 5%.2 Despite the development of novel, complex, multidisciplinary, and targeted therapies the outcome for patients remains almost universally lethal.5 Therefore, the need for effective treatment is undeniable. For this reason, it has been a priority area in cancer research. Recently, US biotech company Northwest Biotherapeutics has developed a brain cancer vaccine, called DCVax, which is designed to help patients' immune system to target their tumors that may prolong their life by months or, in some cases, years.5 Thus, opening a door for the development of innovative therapy for targeting glioblastoma. The vaccine is created for each patient individually by isolating dendritic cells, from their blood which is then primed with biomarkers from a sample of the patient’s tumor.6 Dendritic cells present tumor antigens to the immune system, prime T cells, and mobilize antitumor responses.6 To evaluate the safety of the vaccine and its impact on survival time in patients with Glioblastoma, a phase 3 randomized control trial was conducted.7 In this trial, 348 patients newly diagnosed with Glioblastoma were tested at King’s College Hospital and other centers around the world for 8 years.7 Patients had surgery to remove their tumors as much as possible, followed by radiation and chemotherapy as the standard treatment for Glioblastoma.7 Among these patients, two out of three were treated with the vaccine, DCVax-L, with the remaining one-third receiving a placebo.7 The astonishing result of the trial has shown that newly diagnosed patients who received the vaccine survived for 19.3 months compared to 16.5 months for those who received a placebo.8 Overall 13% of all trial participants treated with DCVax lived more than 5 years after diagnosis compared with 5.7% in the comparison group who did so.8 Moreover, this is the first time in 17 years that such a significant result has been achieved in a Phase 3 trial of a systemic treatment for newly diagnosed Glioblastoma, and it’s the first treatment in 27 years for patients with GBM recurrence.9 Thus, this development represents a major step forward in our efforts to combat this devastating disease. Based on the findings of the trials evaluating the drug’s efficacy, it has the potential to improve the quality of life for patients, especially for the elderly and those unable to have surgery. A global clinical trial has concluded that the DCVax is the world’s first vaccine to treat deadly cancerous brain tumors that could help patients to live for years.9 This breakthrough could benefit 2500 people a year in the UK being diagnosed with Glioblastoma.9 It has also been shown that this therapy can be used to treat cancers other than Glioblastoma.9 However, due to high recurrence rate and lethal outcomes, the treatment of gliblastoma has seen significant transformation, switching from an aggressive surgical strategy to a more cautious one. The endorsement of the vaccine is a commendable achievement, and it demonstrates the unwavering commitment of researchers and healthcare professionals to discovering effective treatments for such lethal disease. Furthermore, vaccine may enhance the quality of life of a patient and provides a new hope for patients and their families Thus, it is crucial that we continue to support research into Glioblastoma and the development of novel treatments so that we can envision a future where this disease is eradicated. Declaration of conflicting interests The author(s) declared no potential conflicts of interest with respect to the research, authorship, and/or publication of this article. Funding The author(s) received no financial support for the research, authorship, and/or publication of this article. ORCID iDs Areeba Fareed
https://orcid.org/0000-0001-5906-9852 Samia Rohail
https://orcid.org/0000-0003-1488-0080 Alishba Adnan
https://orcid.org/0000-0003-1238-6687 Abdul Moiz Khan
https://orcid.org/0000-0001-9796-8867 Footnotes Author’s noteNot commissioned, externally peer reviewed. ContributorshipAreeba Fareed and Samia Rohail wrote the draft. Alishba Adnan and Abdul Moiz Khan proofread it. All authors reviewed and edited the manuscript and approved the final version of the manuscript. Data availabilityNo new dataset generated. References 1. Aans.org. Available from:
https://www.aans.org/Patients/Neurosurgical-Conditions-and-Treatments/Glioblastoma-Multiforme%5d (cited 9 April 2023). GO TO REFERENCE Google Scholar 2. Liau LM, Ashkan K, Brem S, et al. Association of autologous tumor lysate-loaded dendritic cell vaccination with extension of survival among patients with newly diagnosed and recurrent glioblastoma: a phase 3 prospective externally controlled cohort trial: a phase 3 prospective externally controlled cohort trial. JAMA Oncol 2023; 9(1): 112–121. Available from:
https://jamanetwork.com/journals/jamaoncology/fullarticle/2798847 (cited 9 April 2023).
PubMed Google Scholar 3. Pelc C. Experimental cancer vaccine both treats and prevents brain cancer in mice [Internet]. East Sussex, UK: Medical News Today, 2023. Available from:
https://www.medicalnewstoday.com/articles/experimental-cancer-vaccine-both-treats-and-prevents-brain-cancer-in-mice (cited 9 April 2023). GO TO REFERENCE Google Scholar 4. Rong L, Li N, Zhang Z. Emerging therapies for glioblastoma: current state and future directions. J Exp Clin Cancer Res 2022; 41(1): 142. (cited 9 April 2023). GO TO REFERENCE Crossref PubMed Google Scholar 5. Aldape K, Brindle KM, Chesler L, et al. Challenges to curing primary brain tumours. Nat Rev Clin Oncol 2019; 16(8): 509–520. Available from:
https://www.nature.com/articles/s41571-019-0177-5 (cited 9 April 2023).
Crossref PubMed Google Scholar 6. Technology Networks. Brain cancer vaccine shown to extend patient survival [Internet]. Sudbury, UK: Technology Networks, 2022. Available from:
https://www.technologynetworks.com/vaccines/news/brain-cancer-vaccine-shown-to-extend-patient-survival-367721 (cited 9 April 2023).
Google Scholar 7. Clinicaltrials.gov. Study of a drug [DCVax®-L] to treat newly diagnosed GBM brain cancer - full text view - Clinicaltrials.gov [internet]. Bethesda, MD: Clinicaltrials.gov, 2023. Available from:
https://clinicaltrials.gov/ct2/show/NCT00045968 (cited 9 April 2023).
Google Scholar 8. Campbell D. Vaccine shown to prolong life of patients with aggressive brain cancer. London, UK: The guardian [Internet], 2022. Available from:
https://www.theguardian.com/science/2022/nov/17/vaccine-shown-to-prolong-life-patients-aggressive-brain-cancer-trial-glioblastoma (cited 9 April 2023).
Google Scholar 9. Delgado-Martín B, Medina MÁ. Advances in the knowledge of the molecular biology of glioblastoma and its impact in patient diagnosis, stratification, and treatment. Adv Sci 2020; 7(9): 1902971.
Crossref Google Scholar📷 0 Share
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2023.05.29 17:39 vParadox_77 The Definitive Best Armor in KCD
| There is much debate in this sub on the "best" suit of armor that can exist in this game. Some people favor stealth, some favor defense, and some even favor charisma. This post is an attempt to answer this age-old question of what the best suit of armor in KCD really is. Christ be praised. First, we need to decide what defines the "best" suit of armor. The first and primary stat that is most crucial is the defense ratings of the armor. This stat has to triumph over all others because the protection of the body is what armor is really all about. The 2nd stat to be considered is Charisma, because, as we already know, the top-tier plate armor already has bad stealth stats, so it is pointless to prioritize stealth. After charisma, we will prioritize the stealth stats visibility and conspicuousness (they go hand in hand) and finally we will prioritize durability. All of the top armor will already have great durability, so there is no need to pick and choose on this stat, besides, it doesn't change the effectiveness of the armor. Finally, if two pieces have the same stats, the rarer of the two will be chosen. So in total, this is the stat prioritization: - Protection
- Charisma
- Stealth
- Durability
- Rarity
Side note: I agree that there is an argument to be made for the best stealth armor in the game. Finding this balance is much harder and requires a lot of math on my end to perfectly balance the stealth stats with armor effectiveness. So expect that post to come later. Now we may assemble the noblest of armors. I will show everything you need to know about the item including links to the KCD wiki for it so you may learn how to unlock it. Henry Wearing the Suit of Armor HELMET- Name: House of Zoul helmet Item Code: 4f27f774-be02-ea89-51d6-ad7ac35587a2 Why: This helmet has the best protection stats in the game. Link: https://kingdom-come-deliverance.fandom.com/wiki/House_of_Zoul_helmet COIF- Name: Dark padded coif Item Code: 4dcb6884-0be0-ca1b-32e6-e20ccbc58c8f Why: This coif is tied for the best protection stats with the beige variant of the padded coif. They both also have the same charisma stat. However, the dark padded coif has better stealth stats than its beige counterpart. Link: https://kingdom-come-deliverance.fandom.com/wiki/Dark_padded_coif HEAD CHAINMAIL- Name: Noble's mail coif Item Code: 4fbc8b16-6e58-af4e-8b95-59963da5ef96 Why: This head chainmail has the best protection stats in the game. Link: https://kingdom-come-deliverance.fandom.com/wiki/Noble%27s_mail_coif NECK CHAIN- Name: Gold Chain Item Code: 0bf732db-ca19-4f0b-a56f-c83a79806d8f Why: Neck chains do not provide protection and the gold chain is tied with the necklace for the highest charisma from the neck chain slot. However, the gold chain is considerably rarer to come by than the necklace, so the gold chain is chosen. Link: https://kingdom-come-deliverance.fandom.com/wiki/Gold_chain OUTER GARMENT- Name: Quartered combat jacket Item Code: 4e1c3929-0e6d-e0c2-61e0-363f8e7ac289 Why: This outer garment is tied for the best protection stats in the game while having the highest charisma from its counterparts. Link: https://kingdom-come-deliverance.fandom.com/wiki/Quartered_combat_jacket BODY PLATE- Name: House of Zoul cuirass Item Code: 4484294f-244c-3701-8ede-f7a0d10ffbb5 Why: This body plate has the best protection stats in the game. Link: https://kingdom-come-deliverance.fandom.com/wiki/House_of_Zoul_cuirass BODY CHAINMAIL- Name: Long noble hauberk Item Code: 431a2a36-312d-d6b0-ddff-fcaddc294291 Why: The long noble hauberk is tied with the short noble hauberk for the highest protection stats in the game. However, the long noble hauberk is considerably rarer than its short counterpart so it is chosen over it. Link: https://kingdom-come-deliverance.fandom.com/wiki/Long_noble_hauberk BODY GARMENT- Name: Decorated arming doublet (Pale Yellow) Item Code: 4e392593-3a86-318b-65bc-05907a52fe8a Why: There are 6 decorated arming doublets in the game all tied for the best protection stats in the body garment slot. Two of the decorated arming doublets have higher charisma than the rest and one of these two has slightly better stealth stats than its counterpart. Therefore, the Pale Yellow variation of the decorated arming doublet is chosen. Link: https://kingdom-come-deliverance.fandom.com/wiki/Decorated_arming_doublet GLOVES- Name: Nobleman's gauntlets Item Code: 46f0f01a-ec0e-82af-8947-fc15bcf1df82 Why: These gauntlets have the best protection stats in the game. Link: https://kingdom-come-deliverance.fandom.com/wiki/Nobleman%27s_gauntlets ARM ARMOR- Name: Zoul arm plate Item Code: 44d0c3fa-67f0-9c6f-8c87-b0fc7d8b87a6 Why: This arm plate has the best protection stats in the game. Link: https://kingdom-come-deliverance.fandom.com/wiki/Zoul_arm_plate LEG CHAINMAIL- Name: Mail chausses Item Code: 44135951-cf1c-f2fd-15f0-0f0ea223a584 Why: This leg chainmail has the best protection stats in the game. Link: https://kingdom-come-deliverance.fandom.com/wiki/Mail_chausses HOSE- Name: Decorated black hose Item Code: 486fb98b-9cbe-79dd-314a-ac379dfc96b3 Why: This hose is tied with all of the other hoses in the game for protection stats. It is also tied for the highest charisma with the red-white miparti hose. The decorated black hose has far superior stealth stats, however, so it is chosen. Link: https://kingdom-come-deliverance.fandom.com/wiki/Decorated_black_hose LEG PLATE- Name: Zoul leg plate Item Code: 45f77d27-651f-8569-0b73-5617444c269d Why: This leg plate has the highest protection stats in the game. Link: https://kingdom-come-deliverance.fandom.com/wiki/Zoul_leg_plate BOOTS- This slot is taken up by the Zoul leg plate, which means that the stats from the Zoul leg plate also apply to the boot slot. Essentially, since the listed stab defense on the Zoul leg plate is 21, this stat gets applied to the leg plate slot and the boots slot, adding a total of 42 stab defense. RING- Name: Family ring Item Code: 88e2cfca-1f87-40f6-9691-4406676d702c Why: This ring, like all rings, doesn't provide protection stats but it does have the best charisma and durability. Link: https://kingdom-come-deliverance.fandom.com/wiki/Family_ring SPURS- Name: Golden spurs Item Code: af6f2946-ce54-4e38-9b2b-5ab95d5c4777 Why: Spurs do not provide protection, but these spurs have the highest charisma. Link: https://kingdom-come-deliverance.fandom.com/wiki/Golden_spurs Final Stats of the Armor And there we have it! The best suit of armor in the game. The final value of the armor is 21634.1 Groshen. I have also attached pictures of Henry wearing the suit of armor and the final stats of this suit as well. I hope this post goes a long way to finally settling the debate on the best possible suit of armor. Make sure you guys turn up in this suit of armor when you show up to demolish black peter. Christ be praised! submitted by vParadox_77 to kingdomcome [link] [comments] |
2023.05.29 17:39 ResearchChemHQ Melanotan II SWISS CHEMS PROMO CODE
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2023.05.29 17:38 BowelEruption Release Dates For EGO Mowers?
I'm on the fence about getting a battery powered mower and have been researching EGO mowers. Generally when purchasing something above several hundred dollars I like to try to get the latest release/model year of a device to ensure longer term support. EGO lists 10+ mowers on their Quick Compare matrix page
here. Initially I was drawn to the LM2135SP by Wirecutter's recommendation but it seems like that model was released in 2019 or 2020 according to my Googling. Does that align with what you all are familiar with? Just trying to get a relative idea of the release dates of EGO mowers so that I can find the newest model in the middle of the range. Not looking to spend $800+ and was hoping to be closer to $500-700/middle range.
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2023.05.29 17:37 OniiChan8723 H: QE25 combat shotgun+QE15fr pump W: apparel, commandos